Message from the PI
Focusing on the eye and optic nerve, we are investigating why neurons die in blinding diseases, such as glaucoma, and why the retina and optic nerve cannot regenerate or self-repair after injury in mice and human. We are interested in understanding the interplays between neurons and the immune system as well as the gut microbiota. Through the employment of cutting-edge technologies in mouse genetics and molecular and cellular biology, our major goal is to identify disease-causing events and develop mechanism-based therapeutic interventions for treating and reversing vision loss.
Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
Nat Commun. 2018 Aug 10;9(1):3209. Huihui Chen, Kin-Sang Cho, T H Khanh Vu, Ching-Hung Shen, Mandeep Kaur, Guochun Chen, Rose Mathew, M Lisa McHam, Ahad Fazelat, Kameran Lashkari, Ngan Pan Bennett Au, Joyce Ka Yu Tse, Yingqian Li, Honghua Yu, Lanbo Yang, Joan Stein-Streilein, Chi Him Eddie Ma, Clifford J Woolf, Mark T Whary, Martine J Jager, James G Fox, Jianzhu Chen, Dong F Chen
Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential
Cells . 2020 Mar 23;9(3):781 Enayati S, Chang K, Achour H, Cho KS, Xu F, Guo S, Z Enayati K, Xie J, Zhao E, Turunen T, Sehic A, Lu L, Utheim TP, Chen DF.