Publications

2021
Non-invasive electrical stimulation as a potential treatment for retinal degenerative diseases.
Chang K, Enayati S, Cho KS, Utheim TP, Chen DF
Absence of ephrin-A2/A3 increases retinal regenerative potential for Müller cells in Rhodopsin knockout mice.
Zhu RL, Fang Y, Yu HH, Chen DF, Yang L, Cho KS
TNFα activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation.
Niu L, Fang Y, Yao X, Zhang Y, Wu J, Chen DF, Sun X
2020
Therapeutic Targeting of Retinal Immune Microenvironment With CSF-1 Receptor Antibody Promotes Visual Function Recovery After Ischemic Optic Neuropathy.
Tang Y, Xiao Z, Pan L, Zhuang D, Cho KS, Robert K, Chen X, Shu L, Tang G, Wu J, Sun X, Chen DF
The role of commensal microflora-induced T cell responses in glaucoma neurodegeneration.
Tang J, Tang Y, Yi I, Chen DF
CD4+ T-Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy.
Khanh Vu TH, Chen H, Pan L, Cho KS, Doesburg D, Thee EF, Wu N, Arlotti E, Jager MJ, Chen DF
Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential.
Enayati S, Chang K, Achour H, Cho KS, Xu F, Guo S, Z Enayati K, Xie J, Zhao E, Turunen T, Sehic A, Lu L, Utheim TP, Chen DF
Adaptive Immunity: New Aspects of Pathogenesis Underlying Neurodegeneration in Glaucoma and Optic Neuropathy.
Jiang S, Kametani M, Chen DF
Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy.
Prahst C, Ashrafzadeh P, Mead T, Figueiredo A, Chang K, Richardson D, Venkaraman L, Richards M, Russo AM, Harrington K, Ouarné M, Pena A, Chen DF, Claesson-Welsh L, Cho KS, Franco CA, Bentley
2019
Visual Contrast Sensitivity Correlates to the Retinal Degeneration in Rhodopsin Knockout Mice.
Xiao J, Adil MY, Chang K, Yu Z, Yang L, Utheim TP, Chen DF, Cho KS
Polybenzyl Glutamate Biocompatible Scaffold Promotes the Efficiency of Retinal Differentiation toward Retinal Ganglion Cell Lineage from Human-Induced Pluripotent Stem Cells.
Chen TC, She PY, Chen DF, Lu JH, Yang CH, Huang DS, Chen PY, Lu CY, Cho KS, Chen HF, Su WF
Emerging roles for insulin-like growth factor binding protein like protein 1.
Li Y, Zhao E, Chen DF
Neuroinflammation and microglia in glaucoma: time for a paradigm shift.
Wei X, Cho KS, Thee EF, Jager MJ, Chen DF
2018
Author Correction: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.
Chen H, Cho KS, Vu THK, Shen CH, Kaur M, Chen G, Mathew R, McHam ML, Fazelat A, Lashkari K, Au NPB, Tse JKY, Li Y, Yu H, Yang L, Stein-Streilein J, Ma CHE, Woolf CJ, Whary MT, Jager MJ, Fox J
Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.
Chen H, Cho KS, Vu THK, Shen CH, Kaur M, Chen G, Mathew R, McHam ML, Fazelat A, Lashkari K, Au NPB, Tse JKY, Li Y, Yu H, Yang L, Stein-Streilein J, Ma CHE, Woolf CJ, Whary MT, Jager MJ, Fox J
Optimization of Optomotor Response-based Visual Function Assessment in Mice.
Shi C, Yuan X, Chang K, Cho KS, Xie XS, Chen DF, Luo G
Ezh2 does not mediate retinal ganglion cell homeostasis or their susceptibility to injury.
Cheng L, Wong LJ, Yan N, Han RC, Yu H, Guo C, Batsuuri K, Zinzuwadia A, Guan R, Cho KS, Chen DF
IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades.
Guo C, Cho KS, Li Y, Tchedre K, Antolik C, Ma J, Chew J, Utheim TP, Huang XA, Yu H, Malik MTA, Anzak N, Chen DF
2017
Multimodal Regulation Orchestrates Normal and Complex Disease States in the Retina.
Olivares AM, Jelcick AS, Reinecke J, Leehy B, Haider A, Morrison MA, Cheng L, Chen DF, DeAngelis MM, Haider NB
Impact of Storage Temperature on the Expression of Cell Survival Genes in Cultured ARPE-19 Cells.
Pasovic L, Eidet JR, Olstad OK, Chen DF, Lyberg T, Utheim TP
2016
Optic neuropathy and increased retinal glial fibrillary acidic protein due to microbead-induced ocular hypertension in the rabbit.
Zhao J, Zhu TH, Chen WC, Peng SM, Huang XS, Cho KS, Chen DF, Liu GS
Electrical Stimulation as a Means for Improving Vision.
Sehic A, Guo S, Cho KS, Corraya RM, Chen DF, Utheim TP
Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1.
Yan N, Cheng L, Cho K, Malik MT, Xiao L, Guo C, Yu H, Zhu R, Rao RC, Chen DF
Induced Pluripotent Stem Cells: Development in the Ophthalmologic Field.
Wu N, Doorenbos M, Chen DF
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.
Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH 3rd, Ferguson TA, Chen DF, Kaufman RJ, Hu Y
The Silk-protein Sericin Induces Rapid Melanization of Cultured Primary Human Retinal Pigment Epithelial Cells by Activating the NF-κB Pathway.
Eidet JR, Reppe S, Pasovic L, Olstad OK, Lyberg T, Khan AZ, Fostad IG, Chen DF, Utheim TP
2015
Computer-aided analyses of mouse retinal OCT images - an actual application report.
Yu D, Zheng J, Zhu R, Wu N, Guan A, Cho KS, Chen DF, Luo G
Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival.
Ma J, Guo C, Guo C, Sun Y, Liao T, Beattie U, López FJ, Chen DF, Lashkari K
Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5(+) liver cancer initiating cells by suppressing negative regulators of β-catenin signaling.
Lei ZJ, Wang J, Xiao HL, Guo Y, Wang T, Li Q, Liu L, Luo X, Fan LL, Lin L, Mao CY, Wang SN, Wei YL, Lan CH, Jiang J, Yang XJ, Liu PD, Chen DF, Wang B
2014
Ephrin-A2 and -A3 are negative regulators of the regenerative potential of Möller cells.
Zhu R, Cho KS, Chen DF, Yang L
Mobilizing endogenous stem cells for retinal repair.
Yu H, Vu TH, Cho KS, Guo C, Chen DF
2012
The Immunology of Glaucoma.
Vu TH, Jager MJ, Chen DF
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.
Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z
2011
Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage.
Wei X, Yu Z, Cho KS, Chen H, Malik MT, Chen X, Lo EH, Wang X, Chen DF
Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death.
Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR
2010
Dynamic patterns of histone lysine methylation in the developing retina.
Rao RC, Tchedre KT, Malik MT, Coleman N, Fang Y, Marquez VE, Chen DF
2008
Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system.
Jiao JW, Feldheim DA, Chen DF
Promoting optic nerve regeneration in adult mice with pharmaceutical approach.
Cho KS, Chen DF
Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration.
Tucker B, Klassen H, Yang L, Chen DF, Young MJ
alpha-Aminoadipate induces progenitor cell properties of Müller glia in adult mice.
Takeda M, Takamiya A, Jiao JW, Cho KS, Trevino SG, Matsuda T, Chen DF
Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals.
Jiao J, Chen DF
2007
Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin.
Nakazawa T, Takeda M, Lewis GP, Cho KS, Jiao J, Wilhelmsson U, Fisher SK, Pekny M, Chen DF, Miller JW
2006
Characterization of cytokine responses to retinal detachment in rats.
Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H, Skondra D, Miyahara S, Sobrin L, Thomas KL, Chen DF, Grosskreutz CL, Hafezi-Moghadam A, Miller JW
2005
Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.
Feit-Leichman RA, Kinouchi R, Takeda M, Fan Z, Mohr S, Kern TS, Chen DF
Photoreceptor apoptosis in human retinal detachment.
Arroyo JG, Yang L, Bula D, Chen DF
Re-establishing the regenerative potential of central nervous system axons in postnatal mice.
Cho KS, Yang L, Lu B, Feng Ma H, Huang X, Pekny M, Chen DF
Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons.
Jiao J, Huang X, Feit-Leithman RA, Neve RL, Snider W, Dartt DA, Chen DF
2004
Preventing retinal detachment-associated photoreceptor cell loss in Bax-deficient mice.
Yang L, Bula D, Arroyo JG, Chen DF
2003
MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry.
Tian W, Boggs DA, Uko G, Essiet A, Inyama M, Banjoko B, Adewole T, Ding WZ, Mohseni M, Fritz R, Chen DF, Palmer LJ, Fraser PA
Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein.
Lu C, Huang X, Ma HF, Gooley JJ, Aparacio J, Roof DJ, Chen C, Chen DF, Li T
Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin.
Kinouchi R, Takeda M, Yang L, Wilhelmsson U, Lundkvist A, Pekny M, Chen DF
Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism.
Huang X, Wu DY, Chen G, Manji H, Chen DF
2001
Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum.
Holm KH, Cicchetti F, Bjorklund L, Boonman Z, Tandon P, Costantini LC, Deacon TW, Huang X, Chen DF, Isacson O